Lena Brundin
Laboratory

Overview

Behavioral Medicine

The laboratory of Dr. Lena Brundin investigates how inflammation in the periphery and central nervous systems contributes to neurological disorders, such as Parkinson’s disease, and psychiatric symptoms, such as depression, anxiety and suicidal thoughts/behavior.

Inflammation can be caused by many different factors and generates a cascade of cytokines, chemokines and metabolites that have intricate effects on neurons and other brain cells. The details of how inflammation impacts the central nervous system are just beginning to be understood. In our studies, we seek to identify inflammatory changes and link them to neurological symptoms. Through this approach, we aim to find novel therapeutic strategies that target inflammation and improve treatment outcomes.

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  • 88 studies published from Jan. 1, 2022 to Sept. 21, 2022
  • 44 studies in high-impact journals from Jan. 1, 2022 to Sept. 21, 2022
  • 42 clinical trials launched

Lena Brundin, M.D., Ph.D.

Professor, Department of Neurodegenerative Science

Areas of Expertise

Depression, suicide, inflammation, glutamate, perinatal depression, clinical studies, translational research

Biography

Dr. Lena Brundin earned her Ph.D. in neurobiology and her M.D. from Lund University, Sweden, where she specialized in clinical psychiatry and later attained the rank of associate professor. In 2012, she joined Van Andel Institute and Michigan State University College of Human Medicine in Grand Rapids, Mich. She is currently a professor in the Institute’s Department for Neurodegenerative Science.

Dr. Brundin’s research spans basic and clinical research, and focuses on the role of inflammatory mediators in psychiatric and neurological conditions, particularly the effects of the kynurenine metabolic pathway in depression and Parkinson’s disease. Her studies were among the first to indicate a role for inflammatory cytokines in suicidality, a finding that one day may help develop biomarkers for depression and suicide risk. She is currently the principal investigator on an R01-funded clinical trial that investigates the role of the kynurenine pathway in depressive patients with suicide risk. She also analyzes the potential of these metabolites as biomarkers and modulators of disease progression in Parkinson’s disease, funded by the Michael J. Fox Foundation. Further, she pursues studies aimed at identifying triggers of these disorders, such as bacterial, parasitic and viral infections.

Selected Publications

Sha Q, Madaj Z, Keaton S, Escobar Galvis ML, Smart L, Krzyzanowksi S, Fezleabas AT, Leach R, Postolache TT, Achtyes AD, Brundin L. 2022. Cytokines and trytophan metabolites can predict depressive symptoms in pregnancyTransl Psych 12(35).

George S, Tyson T, Rey NL, Sheridan R, Peelaerts W, Becker K, Schulz E, Meyerdirk L, Burmeister AR, von Linstow CU, Steiner JA, Escobar Galvis ML, Ma J, Pospisilik JA, Labrie V, Brundin L, Brundin P. 2021. T cells limit accumulation of aggregate pathology following intrastratial injection of a-synuclein fibrilsJ Park Dis. 11(2):585–603.

Bacelis J, Compagno M, George S, Pospisilik A, Brundin P, Torinsson A, Brundin L. 2021. Decreased risk of Parkinson’s disease after rheumatoid arthritis diagnosis: a nested case-control study with matched cases and controlsJ Parkinson’s Dis.

Li P, Killinger BA, Ensink E, Beddows I, Yilmaz A, Lubben N, Lamp J, Schilthuis M, Vega IE, Woltjer R, Pospisilik JA, Brundin P, Brundin L, Graham SF, Labrie V. 2021. Gut microbiota dysbiosis is associated with elevated bile acids in Parkinson’s diseaseMetabolites 11(1):29.

Sha Q, Achtyes E, Nagalla M, Keaton A, Smart L, Leach R, Brundin L. 2021. Associations between estrogen and progesterone, the kynurenine pathway, and inflammation in the post-partumJ Affect Dis 281:9–12.

George S, Rey NL, Tyson T, Esquibel C, Meyerdirk L, Schulz E, Pierce S, Burmeister AR, Madaj Z, Steiner JA, Escobar Galvis ML, Brundin L, Brundin P. 2019. Microglia affect alpha-synuclein cell-to-cell transfer in a mouse model of Parkinson’s diseaseMol Neurodegener 14:34.

Achtyes E, Keaton SA, Smart L, Burmeister AR, Heilman PL, Krzyzanowski S, Nagalla M, Guillemin GJ, Escobar Galvis ML, Lim CK, Muzik M, Postolache TT, Leach R, Brundin L. 2019. Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depressionBrain Behav Immun.

Keaton SA, Madaj ZB, Heilman P, Smart L, Grit J, Gibbons R, Postolache TT, Roaten K, Achtyes ED, Brundin L. 2019. An inflammatory profile linked to increased suicide riskJ Affect Disord 247:57 65.

Ohlsson L, Gustafsson A, Lavant E, Suneson K, Brundin L, Westin A, Ljunggren L, Lindqvist D. 2018. Leaky gut biomarkers in depression and suicidal behaviorActa Psychiatrica Scandinavica.

Labrie V, Brundin L. 2018. Harbingers of mental illness—infections associated with an increased risk for neuropsychiatric illness in childrenJAMA Psych.

Johnson ME, Stecher B, Labrie V, Brundin L, Brundin P. 2018. Triggers, facilitators and aggravators: Redefining Parkinson’s disease pathogenesisTrends Neurosci.

Killinger BA*, Madaj Z*, Sikora JW, Rey N, Haas AJ, Vepa Y, Lindqvist D, Chen H, Thomas PM, Brundin P, Brundin L, Labrie V. 2018. The veriform appendix impacts the risk of developing Parkinson’sSci Transl Med 10(465):eaar5280.

Thirtamara-Rajamani K, Li P, Escobar Galvis ML, Labrie V, Brundin P, Brundin L. 2017. Is the enzyme ACMSD a novel therapeutic target in Parkinson’s disease?J Parkinson Dis 7(4):577–587.

Brundin L, Sellgren CM, Lim CK, Grit J, Pålsson E, Landén M, Samuelsson M, Lundgren K, Brundin P, Fuchs D, Postolache TT, Traskman-Bendz L, Guillemin GJ, Erhardt S. 2016. An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammationTransl Psychiatry 6:e865.

Coetzee SG, Pierce S, Brundin P, Brundin L, Hazelett DJ, Coetzee GA. In press. Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson’s disease etiologySci Rep.

Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M, Lundberg K, Postolache TT, Träskman-Bendz L, Guillemin GJ, Brundin L. 2013. Connecting inflammation with glutamate agonism in suicidalityNeuropsychopharmacology 38:743–752.

Janelidze S, Ventorp F, Erhardt S, Hansson O, Minthon L, Flax J, Samuelsson M, Träskman-Bendz L, Brundin L. 2013. Altered chemokine levels in the cerebrospinal fluid and plasma of suicide attemptersPsychoneuroendocrinology 38(6):853–862.

Suchankova P, Holm G, Träskman-Bendz L, Brundin L, Ekman A. 2013. The +1444C>T polymorphism in the CRP gene: a study on personality traits and suicidal behaviourPsychiatr Genet 23(2):70-76.

Bay-Richter C, Hallberg L, Ventorp F, Janelidze S, Brundin L. 2012. Aldosterone synergizes with peripheral inflammation to induce brain IL-1β expression and depressive-like effectsCytokine 60(3): 749–754.

Lindqvist D, Kaufman E, Brundin L, Hall S, Surova Y, Hansson O. 2012. Non-motor symptoms in patients with Parkinson’s disease—correlations with inflammatory cytokines in serumPLoS One 7(10): e47387.

Zhang Y, Träskman-Bendz L, Janelidze S, Langenberg P, Saleh A, Constantine N, Okusaga O, Bay-Richter C, Brundin L*, Postolache TT*. 2012. Toxoplasma gondii immunoglobulin G antibodies and nonfatal suicidal self-directed violenceJ Clin Psychiatry 73(8): 1069–1076.
*Shared last authorship

Miguel Aguileta, Ph.D.

Postdoctoral Fellow, Brundin Laboratory

Ehraz Anis, Ph.D.

Postdoctoral Fellow, Brundin Laboratory

Exploring the contribution of the vermiform appendix to Parkinson’s disease

Jaycie Brown

Research Technician, Department of Neurodegenerative Science

Tyce Cave

Research Technician, Department of Neurodegenerative Science

Jamie Durst, B.S.

Senior Administrative Assistant I, Department of Neurodegenerative Science

Qiong (Jade) Sha, Ph.D.

Research Scientist, Department of Neurodegenerative Science

Jennifer Steiner, Ph.D.

Senior Laboratory Manager, Department of Neurodegenerative Science

Emmanuel Quansah, Ph.D.

Research Scientist, Department of Neurodegenerative Science

Pharmacological and epigenetic suppression of alpha-synuclein propagation

Saima Zameer, Ph.D, M.Pharm, B.Pharm

Postdoctoral Fellow, Brundin Laboratory

Lab Alumni

Jonas Bacelis, Ph.D.

Postdoctoral Fellow

Amanda Burmeister, Ph.D.

Postdoctoral Fellow

Colt Capan, M.S.

Research Technician

Cameron Forton, B.S.

Assistant Research Technician

Sonia George, Ph.D.

Research Scientist

Nicole Haefs

Intern

Patrick Heilman, Ph.D.

Postdoctoral Fellow

Nicole Horne

Intern

Christina Houck, B.S.

Assistant Research Technician

Alysa Kasen

Van Andel Institute Graduate School Student

Ella Kasanga, Ph.D.

Postdoctoral Fellow

Sarah Keaton, Ph.D.

MSU Graduate Student

Stan Krzyzanowski, B.A.

Lab Manager

Emily Kuhn, B.S.

Senior Research Technician

Emily Mace, B.S.

Administrative Assistant II