Lena Brundin Laboratory

Selected Publications

George S, Tyson T, Rey NL, Sheridan R, Peelaerts W, Becker K, Schulz E, Meyerdirk L, Burmeister AR, von Linstow CU, Steiner JA, Escobar Galvis ML, Ma J, Pospisilik JA, Labrie V, Brundin L, Brundin P. 2021. T cells limit accumulation of aggregate pathology following intrastratial injection of a-synuclein fibrils. J Park Dis. 11(2):585–603.

Bacelis J, Compagno M, George S, Pospisilik A, Brundin P, Torinsson A, Brundin L. 2021. Decreased risk of Parkinson’s disease after rheumatoid arthritis diagnosis: a nested case-control study with matched cases and controls. J Parkinson’s Dis.

Li P, Killinger BA, Ensink E, Beddows I, Yilmaz A, Lubben N, Lamp J, Schilthuis M, Vega IE, Woltjer R, Pospisilik JA, Brundin P, Brundin L, Graham SF, Labrie V. 2021. Gut microbiota dysbiosis is associated with elevated bile acids in Parkinson’s disease. Metabolites 11(1):29.

Sha Q, Achtyes E, Nagalla M, Keaton A, Smart L, Leach R, Brundin L. 2021. Associations between estrogen and progesterone, the kynurenine pathway, and inflammation in the post-partum. J Affect Dis 281:9–12.

George S, Rey NL, Tyson T, Esquibel C, Meyerdirk L, Schulz E, Pierce S, Burmeister AR, Madaj Z, Steiner JA, Escobar Galvis ML, Brundin L, Brundin P. 2019. Microglia affect alpha-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease. Mol Neurodegener 14:34.

Achtyes E, Keaton SA, Smart L, Burmeister AR, Heilman PL, Krzyzanowski S, Nagalla M, Guillemin GJ, Escobar Galvis ML, Lim CK, Muzik M, Postolache TT, Leach R, Brundin L. 2019. Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression. Brain Behav Immun.

Keaton SA, Madaj ZB, Heilman P, Smart L, Grit J, Gibbons R, Postolache TT, Roaten K, Achtyes ED, Brundin L. 2019. An inflammatory profile linked to increased suicide risk. J Affect Disord 247:57 65.

Ohlsson L, Gustafsson A, Lavant E, Suneson K, Brundin L, Westin A, Ljunggren L, Lindqvist D. 2018. Leaky gut biomarkers in depression and suicidal behavior. Acta Psychiatrica Scandinavica.

Labrie V, Brundin L. 2018. Harbingers of mental illness—infections associated with an increased risk for neuropsychiatric illness in children. JAMA Psych.

Johnson ME, Stecher B, Labrie V, Brundin L, Brundin P. 2018. Triggers, facilitators and aggravators: Redefining Parkinson’s disease pathogenesis. Trends Neurosci.

Killinger BA*, Madaj Z*, Sikora JW, Rey N, Haas AJ, Vepa Y, Lindqvist D, Chen H, Thomas PM, Brundin P, Brundin L, Labrie V. 2018. The veriform appendix impacts the risk of developing Parkinson’s. Sci Transl Med 10(465):eaar5280.

Thirtamara-Rajamani K, Li P, Escobar Galvis ML, Labrie V, Brundin P, Brundin L. 2017. Is the enzyme ACMSD a novel therapeutic target in Parkinson’s disease?J Parkinson Dis 7(4):577–587.

Brundin L, Sellgren CM, Lim CK, Grit J, Pålsson E, Landén M, Samuelsson M, Lundgren K, Brundin P, Fuchs D, Postolache TT, Traskman-Bendz L, Guillemin GJ, Erhardt S. 2016. An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation. Transl Psychiatry 6:e865.

Coetzee SG, Pierce S, Brundin P, Brundin L, Hazelett DJ, Coetzee GA. In press. Enrichment of risk SNPs in regulatory regions implicate diverse tissues in Parkinson’s disease etiology. Sci Rep.

Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M, Lundberg K, Postolache TT, Träskman-Bendz L, Guillemin GJ, Brundin L. 2013. Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology 38:743–752.

Janelidze S, Ventorp F, Erhardt S, Hansson O, Minthon L, Flax J, Samuelsson M, Träskman-Bendz L, Brundin L. 2013. Altered chemokine levels in the cerebrospinal fluid and plasma of suicide attempters. Psychoneuroendocrinology 38(6):853–862.

Suchankova P, Holm G, Träskman-Bendz L, Brundin L, Ekman A. 2013. The +1444C>T polymorphism in the CRP gene: a study on personality traits and suicidal behaviour. Psychiatr Genet 23(2):70-76.

Bay-Richter C, Hallberg L, Ventorp F, Janelidze S, Brundin L. 2012. Aldosterone synergizes with peripheral inflammation to induce brain IL-1β expression and depressive-like effects. Cytokine 60(3): 749–754.

Lindqvist D, Kaufman E, Brundin L, Hall S, Surova Y, Hansson O. 2012. Non-motor symptoms in patients with Parkinson’s disease—correlations with inflammatory cytokines in serum. PLoS One 7(10): e47387.

Zhang Y, Träskman-Bendz L, Janelidze S, Langenberg P, Saleh A, Constantine N, Okusaga O, Bay-Richter C, Brundin L*, Postolache TT*. 2012. Toxoplasma gondii immunoglobulin G antibodies and nonfatal suicidal self-directed violence. J Clin Psychiatry 73(8): 1069–1076.
*Shared last authorship