The research in the laboratory investigates how inflammation in the periphery and the central nervous system can give rise to symptoms of depression, anxiety, and suicidal thoughts/behavior. Inflammation, which can be induced by a variety of causes, generates a cascade of cytokines, chemokines, and metabolites that have intricate effects on neurons and other cells in the brain. The details of the effects of inflammation on the central nervous system are just beginning to be understood. In our studies, we look for inflammatory changes associated with symptoms of depression in psychiatric patients, and we seek to confirm our findings in animal models. The ultimate goal is to find novel therapeutic strategies targeting inflammation that improve treatment outcomes for depression and suicidal tendencies.